Note:  Selected releases translated to English. To see all Nasdaq regulatory releases, see Swedish press releases.


ExpreS2ion and GenIbet sign collaboration agreement for vaccine development and GMP production

ExpreS2ion Biotech Holding AB’s fully owned subsidiary ExpreS2ion Biotechnologies ApS (“ExpreS2ion”) has signed a collaboration agreement regarding vaccine development and GMP (Good Manufacturing Practice) manufacturing with its Portuguese partner GenIbet Biopharmaceuticals, S.A. (“GenIbet”). The agreement strengthens ExpreS2ion’s position as a full-service provider from discovery up to early clinical development.

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ExpreS2ion’s core platform patent allowed in Canada

ExpreS2ion Biotech Holding AB and its affiliate ExpreS2ion Biotechnologies ApS (“ExpreS2ion") announce that the Company’s patent application “Improved Protein Expression System”, that covers the entire ExpreS2 platform, has been allowed in Canada and will be granted with expiry June 12, 2029.

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ExpreS2ion’s U.S. partner Integrated BioTherapeutics launches first ExpreS2-based research product

ExpreS2ion Biotech Holding AB’s fully owned subsidiary ExpreS2ion Biotechnologies ApS (“ExpreS2ion”) announces that its U.S.-based partner and licensee Integrated BioTherapeutics (“IBT”) has initiated sales and marketing of its first ExpreS2-based product. The product, an Ebola virus glycoprotein, is marketed as a part of IBT’s high-quality research protein portfolio and can be used in the development of diagnostic or therapeutic products.

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ExpreS2ion Biotech Holding AB:  Last day of trading in BTA

In February 2018, ExpreS2ion Biotech Holding AB (“ExpreS2ion”) conducted a rights issue of shares in which the public also were given the opportunity to subscribe for shares. Through the rights issue, 2,400,403 shares were issued. Last day of trading in BTAs (paid subscription share) is March 15th, 2018 and stop date is March 19th, 2018. 

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ExpreS2ion’s rights issue oversubscribed

Hørsholm, Denmark, March 2nd, 2018 – ExpreS2ion Biotech Holding AB (“ExpreS2ion”) today announces that the Company’s rights issue of approximately SEK 19.2 million in order to finance investments in several parts of the core business and also to supply additional working capital for future investments in new business opportunities for both ExpreS2ion and AdaptVac, has been oversubscribed. The rights issue was subscribed to approximately SEK 30.3 million, corresponding to a subscription rate of approximately 158 percent. Through the rights issue, a total of 2,400,403 shares are issued and ExpreS2ion is provided approximately SEK 19.2 million before issuing costs. The issuing costs are calculated to amount to approximately SEK 1.3 million. Contract notes are planned to be sent out today, March 2nd, 2018.

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ExpreS2ion Biotech Holding AB announces start of subscription period in the rights issue

Today, on February 8th, 2018, the subscription period in ExpreS2ion Biotech Holding AB’s (“ExpreS2ion”) rights issue, starts. The rights issue is also open to the public. The subscription period ends on February 27th, 2018. A fully subscribed rights issue provides ExpreS2ion with approximately SEK 19.2 million before issuing costs. Beforehand, the company has agreed on subscription commitments amounting to approximately SEK 10.9 million, which equals about 57 % of the rights issue’s total volume. Memorandum, teaser and subscription form are available on the websites of the company (www.expres2ionbio.com) and Sedermera Fondkommission (www.sedermera.se). Subscription through Bank-ID is also available at Sedermera Fondkommission’s website.

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ExpreS2ion resolves on a preferential rights issue to accelerate the Company’s development

Hørsholm, Danmark, January 16, 2018 – ExpreS2ion Biotech Holding AB (”ExpreS2ion”) announces that the Board has decided, pursuant to the authorisation granted by an Extraordinary General Meeting, to carry out a preferential rights issue with the aim to accelerate the Company's development. The preferential rights issue comprises a maximum of 2,400,403 shares with a subscription price of 8.00 SEK per share. The public is also invited to subscribe for shares. Upon full subscription of the rights issue, Expres2ion will raise approximately MSEK 19,203,224 before issue expenses. Beforehand, ExpreS2ion has agreed on subscription commitments amounting to approximately MSEK 10.9, corresponding to approximately 57 percent of the total issue amount, with persons and entities including management, major shareholders and institutions. ExpreS2ion also announces that the Company's Year End Report will be published on February 7, 2018. The previous publication date was February 28, 2018. Notice of the Extraordinary General Meeting will be published shortly. 

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ExpreS2ion’s core platform patent allowed in India

Hørsholm, Denmark, December 28, 2017 – Today, ExpreS2ion Biotech Holding AB and its affiliate ExpreS2ion Biotechnologies ApS (“ExpreS2ion") announce that the company’s patent application “Improved Protein Expression System”, that covers the entire ExpreS2 platform, has been allowed in India and will be granted with expiry June 12, 2029.

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ExpreS2ion and Intravacc enter collaboration agreement

Hørsholm, Denmark / Bilthoven, the Netherlands, December 11, 2017 – Today, ExpreS2ion Biotechnologies ApS (“ExpreS2ion”) and Intravacc (the Institute for Translational Vaccinology), announce the signing of a collaboration agreement. This agreement strengthens ExpreS2ion’s ability to service customers and partners across the full value chain of vaccine development and expands the commercial opportunities for both organisations. Under the agreement, Intravacc will serve as a preferred GMP (Good Manufacturing Practice) partner for ExpreS2ion. The agreement contains no financial exchange between ExpreS2ion and Intravacc. However, it expands the commercial opportunities in the vaccine field for both organisations.

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ExpreS2ion initiates collaboration on in vitro diagnostic products with Institut Virion\Serion GmbH

Hørsholm, Denmark, December 4, 2017 – Today, ExpreS2ion Biotech Holding AB announces that the fully owned subsidiary ExpreS2ion Biotechnologies ApS (“ExpreS2ion”) has entered a collaboration with the Germany based Institut Virion\Serion GmbH (“Virion”).  Virion is granted access to evaluate a number of new in vitro diagnostic product candidates, as well as commercial rights to promote, sell and distribute protein antigens produced using ExpreS2. The financial terms of the agreements are not disclosed, but ExpreS2ion expects to generate annual revenues in excess of 250,000 EUR as a result of these agreements, when the collaboration is implemented.

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Proof of Concept in Animals for AdaptVac’s breast cancer vaccine candidate published in scientific journal

Hørsholm, Denmark, 28 November 2017 – Today, ExpreS2ion Biotech Holding AB announces that the fully owned subsidiary ExpreS2ion Biotechnologies ApS (“ExpreS2ion”)’s 50% owned joint venture, AdaptVac’s, scientific paper presenting proof of concept in animals (POCA) for its novel breast cancer vaccine candidate, AV001, will be published in the peer reviewed scientific journal ‘OncoImmunology’. The results demonstrate that AV001 is effective for both prevention and therapy of breast cancer in an advanced mouse model.

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ExpreS2ion Biotechnologies Announces Research License Agreement with the University of Pennsylvania

Horsholm, Denmark, November 8, 2017 – Today, ExpreS2ion Biotechnologies ApS (“ExpreS2ion”), a fully owned subsidiary of ExpreS2ion Biotech Holding AB, announces that University of Pennsylvania, Philadelphia, USA, has signed a Research License Agreement granting University of Pennsylvania the right to conduct research using ExpreS2ion’s proprietary protein expression system, ExpreS2. 

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ExpreS2ion’s new joint venture, AdaptVac, reaches proof of concept in animals for breakthrough breast cancer vaccine treatment

Hørsholm, Denmark, October 18, 2017 – Today, ExpreS2ion Biotech Holding AB (“ExpreS2ion”) announces that its joint venture, AdaptVac ApS (“AdaptVac”), has reached proof of concept in advanced animal models (POCA) for AV-001, its novel vaccine treatment against breast cancer tumours. This is a significant milestone for AdaptVac in the progress towards clinical development. AdaptVac will now initiate discussions with large pharmaceutical companies regarding a license or collaboration agreement for the clinical development of the project.

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Following its successful rights issue, ExpreS2ion finalises the AdaptVac joint venture

Hørsholm, Denmark, October 2, 2017 – Today, ExpreS2ion Biotech Holding AB announces that the fully owned subsidiary ExpreS2ion Biotechnologies ApS (“ExpreS2ion”) and NextGen Vaccines ApS (“NextGen”) have finalised all agreements for the AdaptVac ApS (“AdaptVac”) joint venture following the successful share issue in August 2017. In addition, ExpreS2ion expects AdaptVac to release additional information on animal data and its primary breast cancer vaccine candidate within the following weeks.

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ExpreS2ion Biotech Holding AB: Last day of trading in BTA

In August 2017, ExpreS2ion Biotech Holding AB (”ExpreS2ion”) conducted a rights issue of shares in which the public was also invited to subscribe for shares. Through the rights issue, 872 873 new shares were issued. The last day of trading in BTA (“Betald tecknad aktie”) is September 21, 2017 and the stop day is September 25, 2017.

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ExpreS2ion Biotech Holding AB: Outcome of rights issue

On 24 August 2017, the subscription period of ExpreS2ion Biotech Holding AB's ("ExpreS2ions") rights issue with a maximum of approx. SEK 3.9 million ended. The rights issue was subscribed at approx. SEK 6 million, corresponding to a subscription rate of approximately 153 percent. Through the rights issue, 872,873 new shares are issued and ExpreS2ion receives approx. SEK 3.9 million before the emission costs of approx. SEK 0.4 million. Settlement notes are due to be sent out today, 30 August, 2017. Note: This is a non-certified English translation of a press release originally drafted in Swedish and published 08:32 CET, 30 August 2017. The Swedish version prevails.

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Today, the subscription period of ExpreS2ion Biotech Holding AB’s rights issue starts

Today, on August 10th 2017, the subscription period in ExpreS2ion Biotech Holding AB’s (”ExpreS2ion”) rights issue of shares is initiated. The subscription period ends on August 24th 2017. A fully subscribed rights issue provides ExpreS2ion approximately SEK 3.9 million before issuing costs. Beforehand, the company has agreed on subscription commitments amounting to approximately SEK 2.2 million, which equals to approximately 57 percent of the rights issue’s total volume. Memorandum, teaser and subscription form are available on the website of the company (www.expres2ionbio.com) and the website of Sedermera Fondkommission (www.sedermera.se).

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ExpreS2ion enters multi-product agreement with US-based Integrated BioTherapeutics for expansion of their commercial reagents portfolio

Hørsholm, Denmark, July 17, 2017 – Today, ExpreS2ion Biotech Holding AB announces that the fully owned subsidiary ExpreS2ion Biotechnologies ApS (“ExpreS2ion”) has entered a Master Services Agreement and a Research & Commercial License Agreement with the US based Integrated BioTherapeutics, Inc. (“IBT”). The agreements enable standardised activation of a range of services and products from ExpreS2ion. This primarily targets the development and manufacturing of proteins based on the ExpreS2 platform, as well as granting IBT commercial rights to promote, sell and distribute such protein products made with ExpreS2. IBT expects to expand their unique research protein portfolio annually with up to five protein antigens manufactured in ExpreS2.  ExpreS2ion and IBT do not disclose the financial terms of the agreements, which constitutes a part of both companies’ general business models, however, when the collaboration is fully implemented, ExpreS2ion expects to generate annual revenues of up to 1.0 million SEK as a result of these agreements. 

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Successful completion of Phase I and initiation of Phase IIa clinical trial of a universal malaria vaccine produced in ExpreS2

Horsholm, Denmark, July 5, 2017 – Today, ExpreS2ion Biotech Holding AB announces that the Jenner Institute of the University of Oxford, a licensee of the fully owned subsidiary ExpreS2ion Biotechnologies ApS (“ExpreS2ion”), initiates recruiting for a Phase IIa clinical trial following a successful Phase I safety study of its new blood stage malaria vaccine. The Phase IIa trial will assess safety, immunogenicity and efficacy of the blood-stage malaria vaccine, which is produced in ExpreS2ion’s proprietary platform, Expres2. Malaria is causing more than 400,000 deaths annually, and the vaccine addresses a global market estimated by The Boston Consulting Group to be in the size of up to $400M per year. 

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ExpreS2ion repositions and gains important ground in the fight against cancer through joint venture

Hørsholm, Denmark, June 28, 2017 – Today, ExpreS2ion Biotech Holding AB announces that the fully owned subsidiary ExpreS2ion Biotechnologies ApS (“ExpreS2ion”) via its ownership in AdaptVac ApS (“AdaptVac”) and the proprietary new Plug-and-Play Virus-Like Particle (VLP) technology, has accelerated the development of efficient therapeutic and prophylactic vaccines within high value segments of oncology, infectious diseases and immunological disorders. This represents a new market focus for ExpreS2ion and a strong repositioning potential due to the shift from being mainly a service provider to also being a developer of vaccines. The risk-adjusted net present value of ExpreS2ion’s stake in AdaptVac’s initial pipeline is estimated to be in the 50-100 million SEK range.

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ExpreS2ion and NextGen enter a Joint Venture for accelerated development of new, improved vaccines and immune therapy

Hørsholm, Denmark, June 21, 2017 – Today, ExpreS2ion Biotech Holding AB announces that the fully owned subsidiary ExpreS2ion Biotechnologies ApS (“ExpreS2ion”) has established a joint venture named AdaptVac ApS with NextGen Vaccines ApS (“NextGen”), a company recently formed by scientists from the University of Copenhagen. AdaptVac has a worldwide exclusive license to a new Plug-and-Play Virus Like Particle (VLP) technology, which enables accelerated development of efficient therapeutic and prophylactic vaccines within high value segments of oncology, infectious diseases and immunological disorders.

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ExpreS2ion signs commercial license agreement with ABIVAX for using the ExpreS2 platform in their Ebola program

Horsholm, Denmark, April 20, 2017 – Today, ExpreS2ion Biotech Holding AB (“ExpreS2ion”), announces that the fully owned subsidiary ExpreS2ion Biotechnologies ApS has entered into a non-exclusive license agreement with ABIVAX S.A. for the commercial use of ExpreS2ion’s expression system, ExpreS2, for their ABX544 Ebola program. The financial terms of the agreement are not disclosed. The agreement follows the term sheet announcement, which ExpreS2ion communicated in a press release on December 12, 2016.

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ExpreS2ion files joint-patent on the production of an improved malaria vaccine with the Walter and Eliza Hall Institute of Medical Research

Horsholm, Denmark, April 6, 2017 – Today, ExpreS2ion Biotech Holding AB (“ExpreS2ion”), announces that the fully owned subsidiary ExpreS2ion Biotechnologies ApS has filed a joint patent application for an improved blood-stage malaria vaccine together with the Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia. This patent positions ExpreS2ion and the Walter and Eliza Hall Institute well for future development of this promising vaccine, addressing a large market with unmet needs. Under a joint vaccine development and patent sharing agreement between ExpreS2ion and The Walter and Eliza Hall Institute, the parties co-own the joint-patent equally.

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ExpreS2ion announces the OptiFemVac Consortium has received final Eurostars approval of its grant application for development of a novel Zika vaccine

Horsholm, Denmark, March 30, 2017 – Today, ExpreS2ion Biotechnologies ApS (“ExpreS2ion”), a fully owned subsidiary of ExpreS2ion Biotech Holding AB, announces the final approval of a Consortium Agreement together with Abera Bioscience AB and the University of Copenhagen, for a Eurostars grant for the project named ‘OptiFemVac’. The approval of the Consortium Agreement triggers a grant of approx. EUR 750,000 of which ExpreS2ion expects to receive approx. EUR 300,000. The approval follows the initial approval which ExpreS2ion Biotech Holding AB communicated in a press release on January 23, 2017.

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ExpreS2ion’s Chief Scientific Officer, Dr. Wian de Jongh, to Speak at ISBiotech 7th Spring Meeting in Washington D.C. – March 6-8

Horsholm, Denmark, February 16, 2017 – Today, ExpreS2ion Biotechnologies ApS (“ExpreS2ion”), a fully owned subsidiary of ExpreS2ion Biotech Holding AB, announces that its Chief Scientific Officer, Dr. Willem Adriaan (“Wian”) de Jongh, is speaking at the ISBiotech 7th Spring Meeting in Washington D.C., USA, on March 6th, 2017, presenting under the headline “Development of Malaria Sub-Unit Vaccines Using the Non-Viral Drosophila S2 Insect Cell Expression System”.   

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ExpreS2ion’s Chief Scientific Officer, Dr. Wian de Jongh, is Appointed Affiliated Associate Professor at the Technical University of Denmark

Horsholm, Denmark, February 14, 2017 – Today, ExpreS2ion Biotechnologies ApS (“ExpreS2ion”), a fully owned subsidiary of ExpreS2ion Biotech Holding AB, announces that its Chief Scientific Officer, Dr. Willem Adriaan (“Wian”) de Jongh, is appointed the honorary position of affiliated associate professor at the Technical University of Denmark (“DTU”). The position is for a duration of five years, commencing in February 2017.   

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ExpreS2ion’s Licensee, VaxInnate, is Winding Down Operations

Horsholm, Denmark, February 9, 2017 – Today, ExpreS2ion Biotechnologies ApS (“ExpreS2ion”), a fully owned subsidiary of ExpreS2ion Biotech Holding AB, announces that VaxInnate Corporation (“VaxInnate”), a US based research licensee, is winding down its operations. This in effect terminates the Research License Agreement announced September 20, 2016. As all payments was received up-front, this has no financial impact on ExpreS2ion.

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ExpreS2ion announces the initial approval of a Eurostars grant application, OptiFemVac, with main focus on the development of a Zika vaccine

Horsholm, Denmark, January 23, 2017 – Today, ExpreS2ion Biotechnologies ApS (“ExpreS2ion”), a fully owned subsidiary of ExpreS2ion Biotech Holding AB, announces that a Eurostars grant application made in a consortium together with Abera Bioscience AB and The University of Copenhagen has been preliminary approved under the project name ‘OptiFemVac’. The overall project budget covers a period of 36 months and amounts to EUR 1.6M. The grant award is approx. EUR 750,000 of which ExpreS2ion can expect to receive in the order of EUR 300,000. The final issue of the grant is linked to the approval of a Consortium Agreement between the OptiFemVac consortium partners.

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ExpreS2ion and ABIVAX announce development collaboration on the Ebola prophylaxis and treatment program, ABX544

Horsholm, Denmark and Paris, France, December 12, 2016 – Today, ExpreS2ion Biotechnologies ApS (“ExpreS2ion”), a fully owned subsidiary of ExpreS2ion Biotech Holding AB, and ABIVAX S.A., (Euronext Paris: FR0012333284 – ABVX), an innovative biotechnology company targeting the immune system to eliminate viral disease, have entered into a service agreement and a term sheet for a commercial license agreement under which ExpreS2ion and ABIVAX collaborate in the development of their proprietary prophylactic and treatment for Ebola virus infection, ABX544. The financial terms of the agreement were not disclosed.

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ExpreS2ion announces the initiation of a Phase I/IIa clinical trial for a new blood-stage malaria vaccine

Horsholm, Denmark, October 18, 2016 – Today, ExpreS2ion Biotech Holding AB (“ExpreS2ion”) announces that its collaboration partner, the Jenner Institute of the University of Oxford, initiates a Phase I/IIa clinical trial to assess the safety, immunogenicity, and efficacy of the blood-stage Plasmodium falciparum malaria antigen RH5.1, which is produced in ExpreS2ion’s proprietary platform, ExpreS2.  

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ExpreS2ion and VaxInnate Sign Research License Agreement

Horsholm, Denmark, September 20, 2016 – Today, ExpreS2ion Biotech Holding AB (“ExpreS2ion”), and VaxInnate Corporation (“VaxInnate”) announce that they have signed a Research License Agreement under which VaxInnate can  conduct vaccine research and preclinical development based on ExpreS2ion’s patented ExpreS2-platform for a year.

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ExpreS2ion Biotech Holding AB’s initial public offering oversubscribed

The 22 June 2016 the subscription period in ExpreS2ion Biotech Holding AB’s (”ExpreS2ion”) initial public offering (”IPO”) of shares at Nasdaq Stockholm First North (”First North”) ended. The IPO was subscribed for approximately 19.2 MSEK inclusive subscription commitments, corresponding to a subscription rate of approximately 107 percent. Through the IPO ExpreS2ion gets approximately 440 new share owners and approximately 18 MSEK before emission costs. The first day of trading is expected to be the 27 July 2016.

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