ExpreS2ion Biotechnologies Announces Research License Agreement with the University of Pennsylvania

Horsholm, Denmark, November 8, 2017 – Today, ExpreS2ion Biotechnologies ApS (“ExpreS2ion”), a fully owned subsidiary of ExpreS2ion Biotech Holding AB, announces that University of Pennsylvania, Philadelphia, USA, has signed a Research License Agreement granting University of Pennsylvania the right to conduct research using ExpreS2ion’s proprietary protein expression system, ExpreS2. 

Read more


ExpreS2ion’s new joint venture, AdaptVac, reaches proof of concept in animals for breakthrough breast cancer vaccine treatment

Hørsholm, Denmark, October 18, 2017 – Today, ExpreS2ion Biotech Holding AB (“ExpreS2ion”) announces that its joint venture, AdaptVac ApS (“AdaptVac”), has reached proof of concept in advanced animal models (POCA) for AV-001, its novel vaccine treatment against breast cancer tumours. This is a significant milestone for AdaptVac in the progress towards clinical development. AdaptVac will now initiate discussions with large pharmaceutical companies regarding a license or collaboration agreement for the clinical development of the project.

Read more


Following its successful rights issue, ExpreS2ion finalises the AdaptVac joint venture

Hørsholm, Denmark, October 2, 2017 – Today, ExpreS2ion Biotech Holding AB announces that the fully owned subsidiary ExpreS2ion Biotechnologies ApS (“ExpreS2ion”) and NextGen Vaccines ApS (“NextGen”) have finalised all agreements for the AdaptVac ApS (“AdaptVac”) joint venture following the successful share issue in August 2017. In addition, ExpreS2ion expects AdaptVac to release additional information on animal data and its primary breast cancer vaccine candidate within the following weeks.

Read more


ExpreS2ion Biotech Holding AB: Last day of trading in BTA

In August 2017, ExpreS2ion Biotech Holding AB (”ExpreS2ion”) conducted a rights issue of shares in which the public was also invited to subscribe for shares. Through the rights issue, 872 873 new shares were issued. The last day of trading in BTA (“Betald tecknad aktie”) is September 21, 2017 and the stop day is September 25, 2017.

Read more


ExpreS2ion Biotech Holding AB: Outcome of rights issue

On 24 August 2017, the subscription period of ExpreS2ion Biotech Holding AB's ("ExpreS2ions") rights issue with a maximum of approx. SEK 3.9 million ended. The rights issue was subscribed at approx. SEK 6 million, corresponding to a subscription rate of approximately 153 percent. Through the rights issue, 872,873 new shares are issued and ExpreS2ion receives approx. SEK 3.9 million before the emission costs of approx. SEK 0.4 million. Settlement notes are due to be sent out today, 30 August, 2017. Note: This is a non-certified English translation of a press release originally drafted in Swedish and published 08:32 CET, 30 August 2017. The Swedish version prevails.

Read more


Today, the subscription period of ExpreS2ion Biotech Holding AB’s rights issue starts

Today, on August 10th 2017, the subscription period in ExpreS2ion Biotech Holding AB’s (”ExpreS2ion”) rights issue of shares is initiated. The subscription period ends on August 24th 2017. A fully subscribed rights issue provides ExpreS2ion approximately SEK 3.9 million before issuing costs. Beforehand, the company has agreed on subscription commitments amounting to approximately SEK 2.2 million, which equals to approximately 57 percent of the rights issue’s total volume. Memorandum, teaser and subscription form are available on the website of the company (www.expres2ionbio.com) and the website of Sedermera Fondkommission (www.sedermera.se).

Read more


ExpreS2ion enters multi-product agreement with US-based Integrated BioTherapeutics for expansion of their commercial reagents portfolio

Hørsholm, Denmark, July 17, 2017 – Today, ExpreS2ion Biotech Holding AB announces that the fully owned subsidiary ExpreS2ion Biotechnologies ApS (“ExpreS2ion”) has entered a Master Services Agreement and a Research & Commercial License Agreement with the US based Integrated BioTherapeutics, Inc. (“IBT”). The agreements enable standardised activation of a range of services and products from ExpreS2ion. This primarily targets the development and manufacturing of proteins based on the ExpreS2 platform, as well as granting IBT commercial rights to promote, sell and distribute such protein products made with ExpreS2. IBT expects to expand their unique research protein portfolio annually with up to five protein antigens manufactured in ExpreS2.  ExpreS2ion and IBT do not disclose the financial terms of the agreements, which constitutes a part of both companies’ general business models, however, when the collaboration is fully implemented, ExpreS2ion expects to generate annual revenues of up to 1.0 million SEK as a result of these agreements. 

Read more


Successful completion of Phase I and initiation of Phase IIa clinical trial of a universal malaria vaccine produced in ExpreS2

Horsholm, Denmark, July 5, 2017 – Today, ExpreS2ion Biotech Holding AB announces that the Jenner Institute of the University of Oxford, a licensee of the fully owned subsidiary ExpreS2ion Biotechnologies ApS (“ExpreS2ion”), initiates recruiting for a Phase IIa clinical trial following a successful Phase I safety study of its new blood stage malaria vaccine. The Phase IIa trial will assess safety, immunogenicity and efficacy of the blood-stage malaria vaccine, which is produced in ExpreS2ion’s proprietary platform, Expres2. Malaria is causing more than 400,000 deaths annually, and the vaccine addresses a global market estimated by The Boston Consulting Group to be in the size of up to $400M per year. 

Read more


ExpreS2ion repositions and gains important ground in the fight against cancer through joint venture

Hørsholm, Denmark, June 28, 2017 – Today, ExpreS2ion Biotech Holding AB announces that the fully owned subsidiary ExpreS2ion Biotechnologies ApS (“ExpreS2ion”) via its ownership in AdaptVac ApS (“AdaptVac”) and the proprietary new Plug-and-Play Virus-Like Particle (VLP) technology, has accelerated the development of efficient therapeutic and prophylactic vaccines within high value segments of oncology, infectious diseases and immunological disorders. This represents a new market focus for ExpreS2ion and a strong repositioning potential due to the shift from being mainly a service provider to also being a developer of vaccines. The risk-adjusted net present value of ExpreS2ion’s stake in AdaptVac’s initial pipeline is estimated to be in the 50-100 million SEK range.

Read more


ExpreS2ion and NextGen enter a Joint Venture for accelerated development of new, improved vaccines and immune therapy

Hørsholm, Denmark, June 21, 2017 – Today, ExpreS2ion Biotech Holding AB announces that the fully owned subsidiary ExpreS2ion Biotechnologies ApS (“ExpreS2ion”) has established a joint venture named AdaptVac ApS with NextGen Vaccines ApS (“NextGen”), a company recently formed by scientists from the University of Copenhagen. AdaptVac has a worldwide exclusive license to a new Plug-and-Play Virus Like Particle (VLP) technology, which enables accelerated development of efficient therapeutic and prophylactic vaccines within high value segments of oncology, infectious diseases and immunological disorders.

Read more


ExpreS2ion signs commercial license agreement with ABIVAX for using the ExpreS2 platform in their Ebola program

Horsholm, Denmark, April 20, 2017 – Today, ExpreS2ion Biotech Holding AB (“ExpreS2ion”), announces that the fully owned subsidiary ExpreS2ion Biotechnologies ApS has entered into a non-exclusive license agreement with ABIVAX S.A. for the commercial use of ExpreS2ion’s expression system, ExpreS2, for their ABX544 Ebola program. The financial terms of the agreement are not disclosed. The agreement follows the term sheet announcement, which ExpreS2ion communicated in a press release on December 12, 2016.

Read more


ExpreS2ion files joint-patent on the production of an improved malaria vaccine with the Walter and Eliza Hall Institute of Medical Research

Horsholm, Denmark, April 6, 2017 – Today, ExpreS2ion Biotech Holding AB (“ExpreS2ion”), announces that the fully owned subsidiary ExpreS2ion Biotechnologies ApS has filed a joint patent application for an improved blood-stage malaria vaccine together with the Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia. This patent positions ExpreS2ion and the Walter and Eliza Hall Institute well for future development of this promising vaccine, addressing a large market with unmet needs. Under a joint vaccine development and patent sharing agreement between ExpreS2ion and The Walter and Eliza Hall Institute, the parties co-own the joint-patent equally.

Read more


ExpreS2ion announces the OptiFemVac Consortium has received final Eurostars approval of its grant application for development of a novel Zika vaccine

Horsholm, Denmark, March 30, 2017 – Today, ExpreS2ion Biotechnologies ApS (“ExpreS2ion”), a fully owned subsidiary of ExpreS2ion Biotech Holding AB, announces the final approval of a Consortium Agreement together with Abera Bioscience AB and the University of Copenhagen, for a Eurostars grant for the project named ‘OptiFemVac’. The approval of the Consortium Agreement triggers a grant of approx. EUR 750,000 of which ExpreS2ion expects to receive approx. EUR 300,000. The approval follows the initial approval which ExpreS2ion Biotech Holding AB communicated in a press release on January 23, 2017.

Read more


ExpreS2ion’s Chief Scientific Officer, Dr. Wian de Jongh, to Speak at ISBiotech 7th Spring Meeting in Washington D.C. – March 6-8

Horsholm, Denmark, February 16, 2017 – Today, ExpreS2ion Biotechnologies ApS (“ExpreS2ion”), a fully owned subsidiary of ExpreS2ion Biotech Holding AB, announces that its Chief Scientific Officer, Dr. Willem Adriaan (“Wian”) de Jongh, is speaking at the ISBiotech 7th Spring Meeting in Washington D.C., USA, on March 6th, 2017, presenting under the headline “Development of Malaria Sub-Unit Vaccines Using the Non-Viral Drosophila S2 Insect Cell Expression System”.   

Read more


ExpreS2ion’s Chief Scientific Officer, Dr. Wian de Jongh, is Appointed Affiliated Associate Professor at the Technical University of Denmark

Horsholm, Denmark, February 14, 2017 – Today, ExpreS2ion Biotechnologies ApS (“ExpreS2ion”), a fully owned subsidiary of ExpreS2ion Biotech Holding AB, announces that its Chief Scientific Officer, Dr. Willem Adriaan (“Wian”) de Jongh, is appointed the honorary position of affiliated associate professor at the Technical University of Denmark (“DTU”). The position is for a duration of five years, commencing in February 2017.   

Read more


ExpreS2ion’s Licensee, VaxInnate, is Winding Down Operations

Horsholm, Denmark, February 9, 2017 – Today, ExpreS2ion Biotechnologies ApS (“ExpreS2ion”), a fully owned subsidiary of ExpreS2ion Biotech Holding AB, announces that VaxInnate Corporation (“VaxInnate”), a US based research licensee, is winding down its operations. This in effect terminates the Research License Agreement announced September 20, 2016. As all payments was received up-front, this has no financial impact on ExpreS2ion.

Read more


ExpreS2ion announces the initial approval of a Eurostars grant application, OptiFemVac, with main focus on the development of a Zika vaccine

Horsholm, Denmark, January 23, 2017 – Today, ExpreS2ion Biotechnologies ApS (“ExpreS2ion”), a fully owned subsidiary of ExpreS2ion Biotech Holding AB, announces that a Eurostars grant application made in a consortium together with Abera Bioscience AB and The University of Copenhagen has been preliminary approved under the project name ‘OptiFemVac’. The overall project budget covers a period of 36 months and amounts to EUR 1.6M. The grant award is approx. EUR 750,000 of which ExpreS2ion can expect to receive in the order of EUR 300,000. The final issue of the grant is linked to the approval of a Consortium Agreement between the OptiFemVac consortium partners.

Read more


ExpreS2ion and ABIVAX announce development collaboration on the Ebola prophylaxis and treatment program, ABX544

Horsholm, Denmark and Paris, France, December 12, 2016 – Today, ExpreS2ion Biotechnologies ApS (“ExpreS2ion”), a fully owned subsidiary of ExpreS2ion Biotech Holding AB, and ABIVAX S.A., (Euronext Paris: FR0012333284 – ABVX), an innovative biotechnology company targeting the immune system to eliminate viral disease, have entered into a service agreement and a term sheet for a commercial license agreement under which ExpreS2ion and ABIVAX collaborate in the development of their proprietary prophylactic and treatment for Ebola virus infection, ABX544. The financial terms of the agreement were not disclosed.

Read more


ExpreS2ion announces the initiation of a Phase I/IIa clinical trial for a new blood-stage malaria vaccine

Horsholm, Denmark, October 18, 2016 – Today, ExpreS2ion Biotech Holding AB (“ExpreS2ion”) announces that its collaboration partner, the Jenner Institute of the University of Oxford, initiates a Phase I/IIa clinical trial to assess the safety, immunogenicity, and efficacy of the blood-stage Plasmodium falciparum malaria antigen RH5.1, which is produced in ExpreS2ion’s proprietary platform, ExpreS2.  

Read more


ExpreS2ion and VaxInnate Sign Research License Agreement

Horsholm, Denmark, September 20, 2016 – Today, ExpreS2ion Biotech Holding AB (“ExpreS2ion”), and VaxInnate Corporation (“VaxInnate”) announce that they have signed a Research License Agreement under which VaxInnate can  conduct vaccine research and preclinical development based on ExpreS2ion’s patented ExpreS2-platform for a year.

Read more


ExpreS2ion Biotech Holding AB’s initial public offering oversubscribed

The 22 June 2016 the subscription period in ExpreS2ion Biotech Holding AB’s (”ExpreS2ion”) initial public offering (”IPO”) of shares at Nasdaq Stockholm First North (”First North”) ended. The IPO was subscribed for approximately 19.2 MSEK inclusive subscription commitments, corresponding to a subscription rate of approximately 107 percent. Through the IPO ExpreS2ion gets approximately 440 new share owners and approximately 18 MSEK before emission costs. The first day of trading is expected to be the 27 July 2016.

Read more