Publications


“Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies”

The ExpreS2 system was used for the production of recombinant PvDBP_RII (SalI) protein for ELISA-based assays in the article “Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies” Abstract BACKGROUND. Plasmodium vivax is the most widespread human malaria geographically; however, no effective vaccine exists. Red blood cell invasion by […]


“Accelerating the clinical development of protein-based vaccines for malaria by efficient purification using a four amino acid C-terminal ‘C-tag’”

The ExpreS2 system was used in the production of  the recombinant protein produced in the study “Accelerating the clinical development of protein-based vaccines for malaria by efficient purification using a four amino acid C-terminal ‘C-tag’” Abstract Development of bespoke biomanufacturing processes remains a critical bottleneck for translational studies, in particular when […]


The ExpreS2 system used in a new study published in Vaccine “Comparison of functional assays used in the clinical development of a placental malaria vaccine”

The article “Comparison of functional assays used in the clinical development of a placental malaria vaccine” was recently published in Vaccine. Abstract BACKGROUND: Malaria in pregnancy is associated with significant morbidity in pregnant women and their offspring. Plasmodium falciparum infected erythrocytes (IE) express VAR2CSA that mediates binding to chondroitin sulphate A […]


The ExpreS2 system is used for production of full-length soluble Plasmodium falciparum RH5 protein vaccine

The article “Production of full-length soluble Plasmodium falciparum RH5 protein vaccine using a Drosophila melanogaster Schneider 2 stable cell line system” was recently published in Scientific Reports. Abstract The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) has recently emerged as a leading candidate antigen against the blood-stage human malaria parasite. However […]


ExpreS2ion Biotechnologies contributes to scientific article

ExpreS2ion Biotechnologies’ scientists contributed to the research for the article by Thrane et al, ”Bacterial superglue enables easy development of efficient virus-like particle based vaccines”, which is published in the Journal of Nanobiotechnology, on 27th April, 2016. The article documents an exciting VLP vaccine platform enabling the binding of complex […]


The Influence of Sub-Unit Composition and Expression System on the Functional Antibody Response in the Development of a VAR2CSA Based Plasmodium falciparum Placental Malaria Vaccine.

“The Influence of Sub-Unit Composition and Expression System on the Functional Antibody Response in the Development of a VAR2CSA Based Plasmodium falciparum Placental Malaria Vaccine” by using the ExpreS2 technology platform compliant with clinical development. Read the article